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A phase 2 trial of semaglutide 2.4 mg in 71 cirrhotic patients confirmed an acceptable safety profile without significant decompensation events, although the primary histological endpoint was not met, possibly due to the limited ability of antifibrotic remodeling to achieve biopsy-detectable fibrosis stage improvement in established cirrhosis over 48 weeks [46]
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Furthermore, a review of the FDA Adverse Event Reporting System (FAERS) data lists allodynia among the top 50 adverse reactions reported with tirzepatide
NYP reported that acute pancreatitis can many times be managed but it can also occasionally cause fatal complications
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