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J Yeungnam Med Sci

SARS-CoV-2 infection leads to m -Dys including mitochondrial membrane depolarization, mitochondrial permeability transition pore opening, increased release of reactive oxygen species (ROS), and disrupted

111,112 Chronic antigen stimulation and age-related inflammation contribute to this shift, accelerating nave T cell decline while promoting memory T cell dominance

P16INK4a upregulation mediated by TBK1 induces retinal ganglion cell senescence in ischemic injury

The increased FAO driven by carnitine leads to an increase in intracellular acetyl-CoA levels, which can be transferred to the nucleus for acetylation of histone H3K27, thereby activating GATA3 gene expression and promoting the differentiation of triple-negative breast cancer cells to the luminal cell state [36]