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HRT Addresses: Estrogen-driven fat redistribution, muscle loss prevention, sleep disruption, hot flashes and night sweats GLP-1 Addresses: Appetite dysregulation, insulin resistance, blood sugar instability, inflammation reduction Combined Benefit: Targets both hormonal AND behavioral factors, which can help preserve lean mass while losing fat and support better energy for lifestyle changes, leading to comprehensive quality of life improvement Rather than competing approaches, hormone optimization therapy and GLP-1 therapy can work through distinct physiological pathways that reinforce each other
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doi: 10.1038/d41586-021-03614-z 32 CampoloJ.BernardiS.CozziL.RocchiccioliS.DellanoceC.CecchettiniA.et al
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Current management strategies mainly involve the use of conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), biological DMARDs, and targeted synthetic DMARDs combined with glucocorticoids to alleviate inflammation and pain [3]
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