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Important caveat: Side effect data comes primarily from animal studies

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Cognitive impairments In rats, supplementation with hydroxytyrosol to males (2 weeks before breeding [64]), resveratrol (G1-P1) [65] or quercetin (G14-19) [58] ameliorated the PRS-induced cognitive impairments in MWM and the T-maze (TM) at one month [64, 65] and only in females in the ORT [58]

These microbial changes correlate with higher lipopolysaccharide (LPS) and lower superoxide dismutase-1 levels (59, 60), which can lead to microbial translocation, systemic inflammation, and increased permeability of both the intestinal and blood-brain barriers (BBB), creating a vicious cycle (6165)

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