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TNB-738 is a biparatopic antibody specifically designed to inhibit CD38 by binding to two distinct epitopes on the CD38 molecule simultaneously, thereby enhancing its inhibitory effect on CD38s enzymatic activity 156

These medications are administered via subcutaneous injection, usually weekly, and require dose titration to minimize gastrointestinal adverse effects
The FDA has indicated it will remove the seven compounds from the interim Category 2 restricted list while the July review proceeds

doi:10.1007/s10456-023-09876-7

The table below shows possible dosage changes for severe cases: Vitamin B12 Injection Dosage for Adults with Malabsorption Adults with malabsorption issues, like those with celiac disease or Crohns disease, might need more B12 injections

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