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Integrating these discoveries into an expanding framework that is meaningful biologically and can be exploited clinically is a growing challenge

Type 2 diabetes, obesity, and metabolic syndrome are all established risk factors for venous and arterial thromboembolism

Regulatory approval was based on the comprehensive phase 3 PIONEER clinical development programme, which demonstrated the efficacy of oral semaglutide versus placebo and most active comparators in achieving glycaemic control and weight loss, with a safety profile consistent with the GLP-1RA drug class [12,13,14,15,16,17]

W., Kim, Y., and Hyun, Y

J.Med.Sci.(Pakistan) 2006;6(5):800-805