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Acknowledgements We thank Laura Weilandt and Sonja Bartholom for help with retrieving literature

Abbreviations CETSA: Cellular thermal shift assay COX2: Cyclooxygenase2 DMSO: Dimethyl sulfoxide GPX4: Glutathione peroxidase 4 GSH: Glutathione H&E: Hematoxylin and eosin IL6: Interleukin6 MDA: Malondialdehyde MMP13: Matrix metallopeptidase 13 OA: Osteoarthritis OSR: Oxysophoridine ROS: Reactive oxygen species SLC7A11: Solute carrier family 7 member 11 TNF: Tumor necrosis factor 4HNE: 4Hydroxynonenal References Singh, N., Bhattacharjee, A., Kumar, P

The characteristics of uniformity cannot always be relied on to differentiate benign from malignant lesions because very early melanomas may appear quite uniform, having a round or oval shape with a uniform brown color

F.et al (2003)