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Huwiler VV, Maissen-Abgottspon S, Stanga Z, et al
This increases the concentration of malonyl-CoA, the first intermediate in fatty acid synthesis, leading to the inhibition of carnitine acyltransferase 1, thereby preventing fatty acid entry into the mitochondrial matrix for oxidation
However, CD3 CAR T cells of LTR exhibited significantly increased mTOR and pS6 expression compared to STR, suggesting a shift from a memory-to-effector metabolic phenotype of LTR CAR T cells from pre- to post-infusion, respectively (Fig
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