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Two randomized control clinical trials reported conflicting effects on bone mineral content (BMC) and bone mineral density (BMD): one trial demonstrated preservation of BMC with GLP-1 use, while the other found no significant difference in BMC or BMD between treatment and control groups

Although gastric banding carries a lower risk of B12 deficiency than malabsorptive procedures such as Roux-en-Y bypass, reduced tolerance of B12-rich foods and the use of acid-suppressing medicines can still compromise nutritional status over time

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for example, about 20.9% average body-weight loss at the 15 mg dose over 72 weeks in SURMOUNT-1