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10.1016/j.ejphar.2024.176905 126 YinW.JiangY.XuS.WangZ.PengL.FangQ.et al (2019)
Both share the same core GHRH(1-29) modified sequence with Aib substitutions at positions 2, 8, 15, and 27
[75] An observational study on patients with obesity and type 2 diabetes and heart failure with preserved ejection fraction reported that tirzepatide had a lower risk of hospitalization for heart failure and all-cause death combined than sitagliptin
Tirzepatide has now been approved for chronic weight management by the FDA in 2023 following the clinical trials data
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