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Synthetic crotamine has since been produced with similar properties to the native peptide, allowing for improved analogs with fewer potential side effects and better properties (de Carvalho Porta et al., 2020)
Data acquisition was using an Agilent 6546 Q-TOF instrument (ESI) with optimized parameters: gas temp 300 C, drying/sheath gas 8/11 L/min, capillary voltage 3500 V, and spray voltages 500/1000 V
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A relatively decrease in IGF-1, which is mainly involved in growth and anabolic processes, leads to decreased tissue regeneration, muscle atrophy, and cognitive decline, leading to age-related disorders (Silverman and Sternberg 2012
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