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The U.S Food and Drug Administration initially rejected it after it appeared to cause several types of tumors in rats, but when a one-year human trial showed no apparent cancer, it was approved, and went on to become one of the most frequently prescribed weight-loss drugs

That survey triggered an unauthorized renewal and shipment of medication they did not request

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Higher body weight is independently associated with increased reflux risk because abdominal fat places additional pressure on the stomach

Weekly consumption and craving Beyond just tracking the number of drinks, the researchers also looked at the subjective experience of craving, that intense desire to drink