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Arai Y, et al

GHK is hydrophilic (water-loving), small, and carries a charge at physiological pH

found that schisandrin B elevated the level of -aminobutyric acid, and significantly decreased the level of glutamate in the peripheral blood of mice and in the cerebral cortex, hippocampus and hypothalamus of rats, which increased the GABA/Glu ratio, thus exerting sedative and hypnotic effects (66)

doi: 10.1158/2326-6066.CIR-15-0210 163 GuntermannCAlexanderDR

Although some promising results have been found in studies on glutathione and skin, there is no conclusive evidence on how to use glutathione as an effective treatment for inflammatory skin conditions