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Under normal physiological conditions, PAD activity is relatively low, but in pathological contexts, citrullination is widely observed in structural proteins, including vimentin, keratin, filaggrin, and core histones (H1, H2A, H3, and H4) ( 174 )

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In SURMOUNT-1, a 72-week trial, adults on the highest branded tirzepatide dose (15 mg) lost roughly 20%

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