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Plasma concentrations of insulin and leptin were measured using a custom developed Mesoscale (MSD) multiplex assay, which is a multi-array assay with electrochemiluminescence readout

AOD-9604 stimulates lipid metabolism and inhibits lipogenesis

AOD-9604 is well soluble, any turbidity indicates degradation or contamination

Melanosis coli is a darkening of the colonic mucosa caused by the accumulation of lipofuscin particles within the macrophages of the lamina propria of the colonic mucosas a result of long term exposure to anthraquinone-containing laxatives

A and B: Before/after pictures: A: Taken at the beginning of the study