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Any adjustments to your medication should be made by a healthcare provider based on lab results and symptoms

Chronic knee pain from osteoarthritis (OA) can significantly impair your daily life, turning simple activities into painful struggles

For research applications, this means that while tirzepatide primarily influences insulin secretion and gastric emptying, retatrutide adds a third layer of glucagon-mediated hepatic glucose production and fatty acid oxidation

[1] [3] Administered as a once-weekly subcutaneous injection, it works by mimicking the action of the naturally occurring hormone GLP-1, which stimulates insulin secretion in response to elevated blood glucose levels, suppresses glucagon release, and slows gastric emptying