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GHK-Cu exerts broad anti-inflammatory effects through its influence on approximately 31% of the human genome, specifically downregulating genes involved in inflammatory processes including interleukin-1, tumor necrosis factor-, and nuclear factor-B (NF-B) signaling while upregulating protective genes encoding antioxidant enzymes, DNA repair proteins, and anti-inflammatory mediators

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Qiaoyue Zhao (Center for Excellence in Molecular Cell Science, CAS) for their assistance in purifying TRIM37 and TRIM28 proteins, and to Qian Yu and Qianwen Wang from the same facility for their support with embryo manipulation