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Importantly, this relationship is relevant to humans as individuals with exceptional longevity are enriched with functional IGF-1R mutations 13 , while low IGF-1 levels predict better survival in female nonagenarians 16

Based on these results, Sung-Jin et al hypothesized that stabilin-1 and stabilin-2 could play an important role in hepatic sequestration of PS-exposed RBCs, suggesting the potential mechanism for the clearance of damaged RBCs by Kupffer cells [273]

Ronald Kahn, Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA

To be used as part of a varied diet and a healthy lifestyle