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Research has demonstrated that: Muscle tissue: Testosterone stimulates muscle protein synthesis through androgen receptor activation, while GH and its downstream mediator IGF-1 promote satellite cell proliferation and myoblast differentiation

Calorie needs should be individualized based on sex, size, and activity level, with most adults avoiding intake below 1000-1200 calories daily without medical supervision

Whilst loss of the normal SOD1 antioxidant enzymatic activity was initially proposed as a cause of neurodegeneration, further research implicated gain of a toxic function instead (Hu et al., 2003)

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Ethics declarations Ethics approval and consent to participate No animal or tissue culture work was carried out in the study