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Diffuse positivity for Melan-A
Many treatments are covered if symptoms interfere with daily life
Dose increases may cause temporary recurrence of tiredness even after initial adaptation
Seiwerth and colleagues (Inflammopharmacology, 1999) documented effects on angiogenic growth factor pathway signalling, and subsequent work has expanded characterisation to include VEGF receptor 2 upregulation, endothelial cell migration in capillary-formation assays, and improved healing in ischemia-reperfusion preparations
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