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Some common causes of vitamin B12 deficiency include: Autoimmune pernicious anemia Dietary limitations, such as vegetarian or vegan diets Medical conditions that affect absorption, such as celiac and Crohns disease Identifying the specific cause of deficiency can help guide treatment and prevention strategies

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This leads to structural change in the photocobilin protein that can promote enzyme activity either through direct fusion to the enzyme domain or by protein-protein interactions

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