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The architecture follows the same long-acting lipopeptide design language as tirzepatide (a chimeric backbone, non-natural amino acid substitutions for protease resistance, a fatty acid modification on a lysine side chain to drive albumin binding) but the receptor-recognition surfaces are tuned to add glucagon-receptor agonism on top of the GIP and GLP-1 dual coverage that tirzepatide provides

Ethics declarations Ethics approval and consent to participate The study was carried out in accordance with the principles outlined in the Declaration of Helsinki and received approval from the Clinical Research Ethics Committee of Renji Hospital, affiliated with the Medical College of Shanghai Jiaotong University (ID LY2023-212-B)

Frequent reordering introduces batch variability one of the most common sources of noise in peptide research

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doi: 10.1016/j.ejphar.2016.04.052 165 HolstJJBurcelinRNathansonE