Pedersen C, Lefevre S, Peters V, Patterson M, Ghatei MA, Morgan LM, et al
How tirzepatide works in the body The mechanism of action of tirzepatide is as follows: Tirzepatide works by activating GLP-1 receptors in the brain and gut, which help regulate appetite and blood sugar levels
Daniel Drucker, MD, then a postdoctoral fellow in the Habener lab, characterized the enzymatic activity of GLP-1, while Jens Juul Holst, MD, at the University of Copehagen, simulatenously discovered GLP-1 regulated insulin secretion
[16] The medication's phase 3 clinical trial program demonstrated reductions in hemoglobin A1c of approximately 1% with the 0.75 mg and 1.5 mg doses of the medication, along with approximately 5 pounds of weight loss on average
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