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In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years

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Importantly, AOD-9604 does not bind to growth hormone receptors, which is why it lacks the glucose-elevating and IGF-1-stimulating effects of full-length growth hormone