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Endpoints of interest were MACE, and when available, major adverse limb events (MALE) including acute limb ischemia and/or amputation

Tirzepatide is a GLP-1 receptor agonist as well, but it also agonizes (initiates or encourages) the hormone GIP

They face chemical instability through hydrolysis and deamidation, and physical instability through aggregation and surface adsorption