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Glutathione transferases (GSTs) help protect cells from oxidative stress and toxic molecules Glutathione peroxidase reduces organic hydroperoxides Glutathione reductase reduces oxidized glutathione back to its active form If glutathione is deficient, the body cannot properly eliminate toxins

However, more serious consequences, such as iron overload and kidney stones, may also result from taking excessive amounts of vitamin C ( Fortunately, you can easily prevent these potential side effects by avoiding high dose vitamin C supplements

Interestingly, a recent study in Danish population showed that lower serum vitamin B12 concentrations were significantly associated higher BMI, but a genetic risk score related to vitamin B12 concentrations associated variants was not associated with BMI

No pressure, right

Acknowledgements This work was funded by the DFG grant DE 1431/20-1 to M.D