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Both increase GH levels, but they do so using distinct biological signals

This biological link is supported by common underlying pathways, such as hepatic and systemic insulin resistance, atherogenic lipid profiles, hypertension, and increased expression of pro-atherogenic, pro-coagulant, and pro-inflammatory factors [75]

The study found no increase in pancreatic cancer risk with GLP-1RA use, and several sensitivity analyses suggested a modest, non-significant reduction in incidence (Wang et al., 2025)

VDAC is not only related to ATP synthesis but is also involved in Bax binding to mitochondria for mitochondrial-mediated apoptosis 32,33