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251 Tumor dormancy and reactivation The dormancy and reactivation of long-established disseminated tumor cells (DTCs) in distant organs following primary tumor resection constitute a pivotal factor contributing to tumor recurrence and pose a significant challenge in antitumor therapy

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Plasma MDA (a lipid peroxidation marker) should decrease or remain stable despite ongoing weight loss if MDA rises while glutathione increases, oxidative stress exceeds antioxidant capacity and dosing adjustments are needed