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Cryo EM dynamics analysis and post-3D classification of CTR:Cagri/CagriBB complex 3D variability analysis (3DVA) implemented in cryoSPARC v4.4.1 29,39 was performed to interrogate and visualize the dynamics in the complexes as previously described 25
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Research on the closely related GHK-Cu demonstrates improved collagen production in treated skin compared to various controls including vitamin C cream and retinoic acid
These structural data reveal a binding mode largely consistent with native amylin, but with notable differences: cagrilintide anchors via the F23 residue and forms a distinctive E14R17 intramolecular salt bridge that stabilizes its receptor-bound conformation
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