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It provides significant reductions in HbA1c levels and offers cardiovascular benefits

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While GLP-1 and GIP signalling primarily enhance insulin secretion and modulate appetite, glucagon receptor activation increases hepatic glucose output, stimulates lipolysis in adipose tissue, and promotes thermogenesis

A 2025 analysis published in Diabetes compared the metabolic effects of semaglutide, tirzepatide, and retatrutide, finding fat mass reductions of 14.3%, 17.2%, and 17.5% respectively [16]

Most states require documented informed consent and patient identity verification for telehealth visits