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Moreover, GLP-1R antagonism partly reduced plasma TGs and this effect could be explained by the GLP-1R-mediated insulin secretagogue effect of G49 that likely accounts for insulin-mediated de novo lipogenesis rather than a direct effect of G49 actions in the liver through the GLP-1R which is nearly absent as reported 54

administered at 75 min, and d-allulose (1 g kg 1 ) or saline was administered at 60 min (Fig

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