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In contrast, the comparison of the lipid profiles between the HFD group and the HFD + EPA group showed significant increases in EPA, Docosahexaenoic acid (22:6n-3) (DHA), and docosapentaenoate (DPA) (22:5n-3), and significant decreases in stearate and arachidonate (20:4n-6) in the latter group (Table 3)
This in turn enables the activation of defense signaling proteins and transcription factors which helps to establish innate immune memory (Lindermayr and Yildirim, 2025)
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Perhaps more importantly for osteoporosis patients, researchers showed that administering additional PEPITEM in animal models of menopause-induced bone loss limited the bone density decline and improved overall bone density
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