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The pathway is also implicated in the exacerbation of asthma symptoms through its interaction with other signaling pathways, such as the endoplasmic reticulum stress pathway, which can be triggered by environmental factors such as diisononyl phthalate exposure [145]

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However, further cross-species studies, long-term ecological monitoring, and in-depth mechanistic explorations are needed in the future to overcome the limitations of current studies

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