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However, the lack of extensive human clinical trials means long-term safety data in humans remains limited

1 These latter effects contribute to the weight-loss benefits of GLP-1RAs, which have since revolutionized the management of obesity

Instead, it may present in test subjects as: Reduced interest in or response to palatable food Blunted response to typically rewarding stimuli Lower apparent motivation or engagement A general observation that reward-related responses appear flattened From a neurobiological perspective, anhedonia is closely linked to dopamine signaling and reward circuitry , particularly in brain regions involved in motivation, anticipation, and reinforcement learning

Whatever you call it, we understand that it may feel awkward to discuss this weight loss side effect