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Furthermore, it is to determine whether the risk may differ by GLP-1RA type, trial duration, control type, and indication

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However, given that pyridoxine is a cocatalyst of many enzymatic processes involved in amino acid metabolisms, such as racemization and decarboxylation, our results do not exclude that pyridoxine may also confer neuroprotection through other undiscovered mechanisms

Table 2 Potential adverse effects of antioxidants

Owing to their effectiveness in reducing body weight, once-daily subcutaneous administration of liraglutide 3.0 mg has been approved, and once-weekly subcutaneous administration of semaglutide 2.4 mg is being investigated in phase III trials, for obesity management