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The interplay between the somatotropic axis and sleep regulation has been extensively documented in both preclinical and clinical studies, demonstrating the integral role of growth hormonereleasing hormone (GHRH), somatostatin, GH itself, insulin-like growth factor-I (IGF-I), synthetic GH secretagogues, and ghrelin in modulating sleep architecture ( In normal individuals, sleep-onset GH secretion appears to be primarily regulated by GHRH stimulation during a period of relative somatostatin withdrawal

Andrew Huberman: If I'm taking vitamin D3, I still need to get out into the sun