Between 2012 and 2014, regulatory authorities approved phentermine/topiramate extended-release, liraglutide (3 mg/day), and naltrexone/bupropion extended-release, which achieved sustained weight loss (12)
Look for symptoms of dehydration such as increased thirst, rapid heartbeat, dry mouth, headaches, lightheadedness, and muscle cramps
However, discontinuation specifically due to adverse events was higher with Retatrutide: 18.2% at the 12mg dose compared to 4.0% with placebo
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