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MOTS-c has attracted considerable scientific interest because of its role in metabolism, and early human studies have begun, but there is currently insufficient evidence to support its use for obesity or osteoporosis, Dr

For instance, female mice administered BSO exhibited much higher susceptibility to acetaminophen-induced hepatotoxicity than male mice [43], while male mice treated with BSO were much more susceptible to thiabendazole nephrotoxicity than females [44]

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This approach serves several distinct clinical needs: patients with high sensitivity to GLP-1 side effects, those maintaining weight loss without needing aggressive appetite suppression, and individuals seeking a carefully managed introduction to incretin therapy