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Compared to other established diabetes medications: Metformin Mounjaro offers greater HbA1c reduction (2.0% vs 1.0-1.5%) and promotes weight loss rather than weight neutrality, but costs significantly more and requires injection rather than oral administration SGLT2 inhibitors (e.g., empagliflozin, dapagliflozin) SGLT2 inhibitors have established cardiovascular and renal benefits from outcome trials

Studies in animal models show that GLP-1 receptor agonists can reduce brain inflammation and improve cognitive function

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Changes in the rectal bleeding subscore, stool frequency subscore, symptomatic response, and symptomatic remission were apparent by Week 2 in both groups, and tended to be better in the ozanimod group from Week 5 onward

GLP-1 agonists mimic the GLP-1 hormone by binding to GLP receptors and triggering the same effects