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36, 37 Its protective role has been ascribed to the ability to inhibit the activation of the caspase cascade

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Phases of metabolism: Phase I metabolism: Oxidation, reduction or hydrolysis Occurs in the liver Usually involves CYP450 Often involves breaking down chemical bonds Makes the molecule more polar

For example, the sub-cutaneous injection study in cats showed measurable increases in delta wave sleep

Lebers disease (hereditary optic nerve atrophy) Polycythemia vera Low potassium levels (hypokalemia) History of blood clots Preparation Details Avoid alcohol when receiving B12 shots