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This directly complicates patient screening and enrollment, leads to substantially lower overall expected efficacy compared with patients harboring upstream genetic defects (such as POMC deficiency) [56] , and results in a low statistical success rate in large-scale trials
Whereas retatrutide brings on the effects of three: GLP-1, GIP, and GCG
(2022) 8:e09394
Often, the next test is serum methylmalonic acid (MMA), a functional marker of B12 deficiency that's produced when there's not enough active vitamin B12 present
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