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Among approved drugs, tirzepatide (Mounjaro/Zepbound) produced the largest average weight loss in trials, about 20.9% over 72 weeks at the highest dose in SURMOUNT-1, ahead of semaglutide at roughly 14.9% over 68 weeks in STEP 1
The glucagon receptor addition in retatrutide appears to ramp up its velocity, making it a compelling choice for those requiring something more aggressive
Management: Use cautiously, especially in patients with cardiovascular conditions
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Eating a high-protein diet: This helps preserve lean muscle mass as you lose weight
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