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Common GI side effects (nausea, diarrhea) are usually mild and transient

Possible positive effects that some patients report include: Improved mood and reduced anxiety symptoms potentially linked to successful weight loss and better metabolic control [6] Enhanced self-esteem and body image as weight reduction progresses Reduced food-related anxiety and preoccupation with eating, though evidence for effects on binge eating is limited and observational Better sleep quality in some patients, though this is anecdotal and not well-established in clinical trials These improvements, when they occur, are generally considered secondary to metabolic benefits rather than direct anxiolytic effects

Numerous studies have demonstrated that meals high in carotenoids, such as tomatoes and their products, provide better protection against lipid peroxidation caused by 1 O 2 , resulting in enhanced antioxidant defense of plasma low-density lipoproteins [154,155,156,157]

Assuming approval, retatrutide could potentially be available by late 2026 to early 2027, though regulatory delays could push this into 2028

No serious adverse events have been widely reported in the literature, but long-term safety is still being evaluated