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To this end a merely speculative but intriguing hypothesis is that PAC adoption might have contributed to the high virulence of COVID-19 observed in many EU countries and USA

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Moreover, acetylation of HMGB1, a damage-associated molecular pattern molecule (DAMP), is released by ferroptosis cells in an autophagy-dependent manner (Wen et al., 2019)

More recently, gene rearrangements have been reported that give rise to AR versions that lack a functional ligand-binding domain (so-called AR variants (ARvs), making them unresponsive to ADT and constitutively active even in the absence of androgens [36]