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The recent FLOW trial with semaglutide in patients with chronic kidney disease and T2DM, with a composite of major kidney disease events as the primary outcome, showed significant reductions in both cardiovascular mortality (HR 0.71

Concurrent medications may influence outcomes

"And there's minimal evidence on the side effects or consequences of long-term or frequent dosing." "It's great to see that we're on this route of health, wellness and recovery, but we need more evidence and research before we can make a true recommendation," he said

So, its best to avoid injecting directly into a nodule or thick skin if you notice it