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Eli Lilly developed the peptide as the next step beyond dual incretin agonists such as tirzepatide, and researchers now study it across obesity, type 2 diabetes and metabolic liver disease

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Concurrent deficiencies in vitamin D, likely due to reduced sunlight exposure, and fluctuations in estradiol, progesterone, and DHEAS, especially among premenopausal women and extreme chronotypes, further exacerbate endocrine disruption 272

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