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10.3171/jns.2004.100.4.0672 334 NavratilA
W., & Schaefer, E
Motor cortex cultures P3 motor cortices isolated from WT-UeGFP, and prpTDP-43 A315T UeGFP mice, dissected, dissociated, and cultured on glass coverslips (4 10 4 cells per 18 mm diameter coverslip, Fisherbrand) coated with poly-L-lysine (10 mg/mL, Sigma)
Visible changes in brightness and evenness of skin tone may take several weeks to months, depending on baseline pigmentation, dose, route of administration, and adherence to sun protection. Results are often subtle and natural-looking, and ongoing maintenance may be required to sustain benefits, especially in individuals with high sun exposure
Dropping from daily to three-times-weekly extends remaining supply while maintaining some benefit
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