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Nrf2, a member of the capncollar family of basic regionleucine zipper transcription factors involved in transcription of antioxidant genes in response to xenobiotic stress, is also a critical regulator of cellular oxidative stress in sepsis (Kolls, 2006) and a regulator of exacerbated proinflammatory cytokine release (cytokine storm) and loss of T lymphocytes (leukopenia) that characterize the most aggressive presentation of SARS-CoV-2-mediated COVID-19 infection (Kobayashi et al., 2016
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It is produced within the body and found in high concentrations in several tissues
Jones DP, Coates RJ, Flagg EW, et al
234 Alarmingly, contamination with heavy metals, pesticides, or undisclosed pharmaceuticals like corticosteroids has been reported in various herbal products, amplifying toxicological risks
