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Eli Lilly & Company
doi:10.1152/ajpendo.00201.2006 Ghigo E, Arvat E, Muccioli G, Camanni F
These microbial metabolites orchestrate oxidative stress modulation through integrated mechanisms: Within the intestinal microenvironment, butyric and propionic acids reinforce epithelial barrier integrity through histone deacetylase (HDAC) inhibition, concomitant stimulation of MUC2 mucin biosynthesis/secretion, and enhanced expression of tight junction proteins (occludin and ZO-1) [57,58,59,60,61,62]
In some cases, referral to rheumatology or orthopedics may be appropriate
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