However, it lost to Mounjaro in a head-to-head trial in February 2026, leading to a shocking result where Novo Nordisk's stock price plummeted by about 15% in one day
Across the GLP-1 class, approved uses include type 2 diabetes, chronic weight management for specific brands, cardiovascular risk reduction in type 2 diabetes for several products, and obstructive sleep apnea in adults with obesity for Zepbound as of 2024
The FDAs prior warnings regarding the potential elevated risk of medullary thyroid carcinoma associated with GLP-1 RAs may encourage more patients on GLP-1 RA therapy to undergo thyroid ultrasounds, thereby enhancing tumor detection
Clinical trials show that patients who discontinue GLP-1 therapy experience a return of hunger signals and metabolic slowdown within weeks, making sustained weight loss extremely difficult without ongoing treatment
Ideally, a product would have both